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Public release date: 28-Mar-2012
Share ] Contact: Mary Todd Bergman
contactpress@ebi.ac.uk
44-122-349-4665
European Molecular Biology Laboratory - European Bioinformatics Institute
Like people bustling around busy cities, the thousands of molecules inside our cells are constantly interacting with each other: turning each other on or off, working together, splitting up and networking. Understanding the countless ways in which they do so is a major challenge in biology, but it is fundamental to understanding life. Scientists at the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI) and colleagues in the International Molecular Exchange (IMEx) consortium are rising to the challenge by offering researchers a freely available set of experimental interaction data that can be queried from a single interface. Reporting in Nature Methods, IMEx partners describe the advantages of their service and invite others to join the effort.
To make it easier to create a picture of an organism's 'interactome' the interactions between all of its molecules IMEx partners have been working since 2004 to create a one-stop-shop for interaction data. A single standard for curating protein interaction data now makes it much simpler for scientists to identify which protein interactions are supported by the strongest evidence.
"There are over 100 interaction databases available, but none of them holds enough information to describe the interactome of any organism," explains Sandra Orchard of the EMBL-European Bioinformatics Institute (EMBL-EBI) in the UK. "In addition to the problem of repeated data entries in these databases, only around 1% of the 151 million binary pairs available are reliable data from published experimental work." The remaining data are theoretical, or the product of text mining; as such, they are far less dependable.
"We've now made it easier to find information about proteins that interact with a given molecule, and to compare new experimental results with publicly available, curated experimental data," says Gianni Cesareni of the University of Rome 'Tor Vergata' in Italy.
"IMEx web services now display curated, experimental data from several reputable resources so that a clearer picture of interactions between proteins can begin to emerge," says Henning Hermjakob, head of Proteomics Services at EMBL-EBI. "We are in effect optimising the return on public investment in interaction databases by co-ordinating global annotation efforts. We are certainly looking forward to having more curated data resources join the consortium."
###
IMEx partners currently include DIP (the Database of Interacting Proteins at UCLA in the US), I2D (at the Ontario Cancer Institute in Canada), InnateDB (Simon Fraser University and the University of British Columbia in Canada and the Teagasc Bioscience Department in Ireland), IntAct (at EMBL-EBI); MatrixDB (at CNRS / Lyon1 University in France), MINT; Molecular Connections (in Bangalore, India); MPIDB (at the J. Craig Venter Institute in the US); observer BioGRID (the Biological General Repository for Interaction Datasets) and the most recent member, the Swiss-Prot group from the SIB Swiss Institute of Bioinformatics, representing the UniProt consortium. IMEx is an outcome of PSIMEx, which is funded under the Health Theme of the European Commissions Seventh Framework Programme.
Explore IMEx at www.imexconsortium.org
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 28-Mar-2012 Share ] Contact: Mary Todd Bergman
contactpress@ebi.ac.uk
44-122-349-4665
European Molecular Biology Laboratory - European Bioinformatics Institute
Like people bustling around busy cities, the thousands of molecules inside our cells are constantly interacting with each other: turning each other on or off, working together, splitting up and networking. Understanding the countless ways in which they do so is a major challenge in biology, but it is fundamental to understanding life. Scientists at the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI) and colleagues in the International Molecular Exchange (IMEx) consortium are rising to the challenge by offering researchers a freely available set of experimental interaction data that can be queried from a single interface. Reporting in Nature Methods, IMEx partners describe the advantages of their service and invite others to join the effort.
To make it easier to create a picture of an organism's 'interactome' the interactions between all of its molecules IMEx partners have been working since 2004 to create a one-stop-shop for interaction data. A single standard for curating protein interaction data now makes it much simpler for scientists to identify which protein interactions are supported by the strongest evidence.
"There are over 100 interaction databases available, but none of them holds enough information to describe the interactome of any organism," explains Sandra Orchard of the EMBL-European Bioinformatics Institute (EMBL-EBI) in the UK. "In addition to the problem of repeated data entries in these databases, only around 1% of the 151 million binary pairs available are reliable data from published experimental work." The remaining data are theoretical, or the product of text mining; as such, they are far less dependable.
"We've now made it easier to find information about proteins that interact with a given molecule, and to compare new experimental results with publicly available, curated experimental data," says Gianni Cesareni of the University of Rome 'Tor Vergata' in Italy.
"IMEx web services now display curated, experimental data from several reputable resources so that a clearer picture of interactions between proteins can begin to emerge," says Henning Hermjakob, head of Proteomics Services at EMBL-EBI. "We are in effect optimising the return on public investment in interaction databases by co-ordinating global annotation efforts. We are certainly looking forward to having more curated data resources join the consortium."
###
IMEx partners currently include DIP (the Database of Interacting Proteins at UCLA in the US), I2D (at the Ontario Cancer Institute in Canada), InnateDB (Simon Fraser University and the University of British Columbia in Canada and the Teagasc Bioscience Department in Ireland), IntAct (at EMBL-EBI); MatrixDB (at CNRS / Lyon1 University in France), MINT; Molecular Connections (in Bangalore, India); MPIDB (at the J. Craig Venter Institute in the US); observer BioGRID (the Biological General Repository for Interaction Datasets) and the most recent member, the Swiss-Prot group from the SIB Swiss Institute of Bioinformatics, representing the UniProt consortium. IMEx is an outcome of PSIMEx, which is funded under the Health Theme of the European Commissions Seventh Framework Programme.
Explore IMEx at www.imexconsortium.org
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-03/embl-mno032812.php
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Source: http://www.co-next.net/take-this-advice-to-become-productive-at-the-home-based-business/
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by Trevor Kenealy
Becoming a Construction Industry Professional
There is an expansive list of professions in the realm of construction. There are engineers, architects, designers, accounting personnel, etc. Many professionals are seeking job positions in this sector. These jobs appeal particularly to most of today?s fresh graduates.
The number of people seeking employment in this sector is spread across various locations. You must have the ability to multi-task if you are hoping to make your career in this industry. Nowadays, job openings in the construction industry, just like any other industries, are posted online and you might be able to an opportunity in there. There might also be opportunities in similar fields outside of your area that you are willing to take on.
The job positions in this industry are not limited to construction only. In other words, it does not mean that a construction manager has to merely supervise or oversee actual construction work. His work include not only managing the workers at the construction area but some other outdoor and indoor assignments. He may be delegated with duties and responsibilities that are crucial for the business, for instance, to keep track of project schedules, their allocated budget, and other tasks which are in line with the company?s objectives of earning profits. In other words, a construction manager is delegated with plenty of major responsibilities.
Being a construction manager is only one of the various job description probabilities. There is a range of options from entry level construction jobs, to There is a diversity of job opportunities ranging from clerical or administrative to the construction managerial levels. Given the diverse selection of professions within the construction industry, getting an employment in a position that is best suitable to your qualifications is still not very easy. On the other hand, there are some useful tools that can assist you in finding the most suitable job, which could be verbally, through the Internet, the periodicals, and others. Actually, there are some websites that are entirely dedicated to the construction industry where you can quickly and easily search for construction employment opportunities.
They have been providing professionals who are interested in the construction industry with the best job possibilities. There are a few sites that provide a career data bank where you can submit your job profile qualifications. You will also be able to find assistance when it comes to other information within the construction business in these sites.
When we talk about the construction industry, it actually encompasses a diversified range of professionals working in this particular field. Construction work is usually carried out in alliance with other people as well as companies in the completion of various projects. Although we generally associate people who work in the construction business as ?construction workers?, many of them are beyond that classification in terms of intellectual capacity and expertise. Even if there is a diversity of profession in the construction environment, getting employment in this sector that is equivalent to your eligibility and aptitude is not going to be that simple.
For more articles visit ArticleDistribution.OrgFiled under: Career
Source: http://articlepromotion.org/blog/?p=87585
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ScienceDaily (Mar. 23, 2012) ? Geophysics researcher Cherish Bauer-Reich wants to look inside the sun. More accurately, she wants to simulate the sun to study plasma flows associated with sunspot cycles. The cycles play a role in solar storms, which can affect satellites and disrupt a host of modern communication technologies, from cell phones to power grids.
Scientists recently warned about a series of solar storms in early March, concerned that it could affect global positioning systems, power grids, satellites and airplane travel. With the sun's normal cycle, these very active solar storms are expected to continue.
Bauer-Reich, a research engineer at North Dakota State University's Center for Nanoscale Science and Engineering, is pursuing her doctorate degree in geophysics, using supercomputing power to create a model of the sun. The Center for Computationally Assisted Science and Technology (CCAST) at North Dakota State University provides the power for Bauer-Reich's research. She found that CCAST in Fargo provided an easily accessible route to the supercomputing needed. NDSU's supercomputing center (CCAST) is available to students, faculty and staff researchers, and available for researchers and industry that are partnering with NDSU.
While people have heard of sunspots, most aren't aware of what actually causes them. "It's a large tube of magnetic flux basically," says Bauer-Reich. "Sunspots reduce the amount of heat and the amount of light coming out of the sun, which is why they look dark. It's because they're at different temperatures than the rest of the area around them."
Sunspots tend to work in cycles, starting at high latitudes and then migrating toward the equator. "Helioseismologists study vibrations in the sun and they image what's underneath the outer layer. What they've found is that when these sunspots are popping up, there's also a flow right next to them, so that the plasma is flowing at a different speed than on either side of them. What I'm studying is how strong that flow has to be," says Bauer-Reich. "The only way to do it is to come up with these models that try to predict behavior."
Bauer-Reich expects running all the computer models on CCAST will take approximately a year, followed by the data analysis. According to Dr. Martin Ossowski, CCAST director, major research areas at the facility include: materials science, renewable energy, multiprocessor electronic circuitry, simulation of atmospheric plasma, monitoring the health of bridges and vehicles, computational biology, tissue engineering, and agroinformatics.
"We assist researchers who are pursuing discovery in energy, materials, environment, health, security, and in other areas of national research priority," said Ossowski. He notes today's supercomputing environment emphasizes not only speed, but the ability to help researchers tailor software to conduct their research, and meet researchers' data lifecycle needs.
Supercomputing is as important to business as it is to scientific researchers. In a white paper titled "Global Leadership Through Modeling and Simulation," the U.S. Council on Competitiveness said "to out-compete is to out-compute." For example, Boeing used a national supercomputing center to accelerate design of the 787 and 747-8 airliners and Navistar Corp. designed technologies for better fuel efficiency in trucks.
The need for supercomputing facilities and those with specialized skills is expected to grow. According to Ossowski, the line between computer programmers and scientists is increasingly blurry. He notes that there will be an increasing need for interdisciplinary research teams, as well as for scientists who are algorithm and code developers, and for programmers who are scientists. "It represents a critical shift in how research problems are approached."
CCAST at NDSU provides high performance computing infrastructure for the university, its Research and Technology Park and their industrial partners, and engages in its own original research.
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The above story is reprinted from materials provided by North Dakota State University, via Newswise.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
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Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
Source: http://www.sciencedaily.com/releases/2012/03/120323093651.htm
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